Scientist from the Transplantation Centre, Mayo Clinic in Phoenix, Arizona reported the case of a 52-year-old woman who suffered acute liver failure requiring a liver transplant after taking 1,000 milligrams per day of the herbal supplement Garcinia cambogia (USA Nutra Labs) for 25 days. A study by researchers from South Korea showed that obese mice consuming a high -fat diet supplemented with Garcinia cambogia showed reduced abdominal fat levels and smaller fat cells compared to animals given a placebo (fake Garcinia). Animals receiving the supplement showed increased activity in genes involved in fat metabolism. However, the supplement impaired blood sugar regulation and had significant side effects in the liver that included increased connective tissue formation, cell membrane destruction and oxidative stress. Garcinia cambogia might pose unacceptable health risks, and bodybuilders should avoid it.